主要文件

查看所有文档

616454

A 83-01

Name: A 83-01
Brand: MM

≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem

别名:

TGF-β RI 激酶抑制剂 IV

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₅H₁₉N₅S

化学文摘社编号:

909910-43-6

分子量:

421.52

MDL number:

MFCD08705403

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

200

Storage condition:

OK to freeze, protect from light

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

TGF-β RI 激酶抑制剂 IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

Quality Level

200

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1

InChI

1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

InChI key

HIJMSZGHKQPPJS-UHFFFAOYSA-N

说明

General description

一种细胞渗透性三取代吡唑化合物，已显示在表达单个I型TGF-β受体的Mv1Lu R4-2转染子中选择性抑制ALK-4/5/7介导（荧光素酶转录活性测定中IC₅₀分别为45、12和7.5 nM），但不抑制ALK-1/2/3/6介导的细胞信号。在浓度为1 µM的情况下，抑制HaCaT细胞中TGF-β-诱导的Smad2磷酸化和NMuMG细胞中的上皮间质转化。

Biochem/physiol Actions

主要靶标
ALK-4/5/7

产物不与ATP竞争。

可逆：否

细胞可渗透性：是

靶标IC₅₀：抑制ALK-4/5/7介导的荧光素酶转录活性测定分别为45、12和7.5 nM

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

Other Notes

Tojo, M., et al. 2005.Cancer Sci.96, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：有害（C）

Still not finding the right product?

Explore all of our products under TGF-β RI 激酶抑制剂 IV

存储类别

11 - Combustible Solids

wgk

WGK 3

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Inhibition of Microglial TGFβ Signaling Increases Expression of Mrc1.

Alexander von Ehr et al.

Frontiers in cellular neuroscience, 14, 66-66 (2020-04-17)

Microglia are constantly surveying their microenvironment and rapidly react to impairments by changing their morphology, migrating toward stimuli and adopting gene expression profiles characterizing their activated state. The increased expression of the M2-like marker Mannose receptor 1 (Mrc1), which is

Imaging-Based Machine Learning Analysis of Patient-Derived Tumor Organoid Drug Response.

Erin R Spiller et al.

Frontiers in oncology, 11, 771173-771173 (2022-01-08)

Three-quarters of compounds that enter clinical trials fail to make it to market due to safety or efficacy concerns. This statistic strongly suggests a need for better screening methods that result in improved translatability of compounds during the preclinical testing

TGFβ1 increases microglia-mediated engulfment of apoptotic cells via upregulation of the milk fat globule-EGF factor 8.

Björn Spittau et al.

Glia, 63(1), 142-153 (2014-08-19)

Milk fat globule-epidermal growth factor-factor 8 (Mfge8) has been described as an essential molecule during microglia-mediated clearance of apoptotic cells via binding to phosphatidylserine residues and subsequent phagocytosis. Impaired uptake of apoptotic cells by microglia results in prolonged inflammatory responses

全球贸易项目编号

货号	GTIN
616454-2MG	04055977185867