627610
Z-VAD-FMK
Solid, Caspase inhibitor, Calbiochem
别名:
半胱天冬酶抑制剂I, Z-VAD (OMe)-FMK
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关于此项目
经验公式（希尔记法）:
C22H30FN3O7
化学文摘社编号:
分子量:
467.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
半胱天冬酶抑制剂I, Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
DMSO: 50 mM
shipped in
ambient
storage temp.
−20°C
SMILES string
FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
InChI
1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI key
MIFGOLAMNLSLGH-QOKNQOGYSA-N
General description
一种细胞可渗透、不可逆的泛半胱天冬酶抑制剂。显示可提高人类胚胎干细胞的冻融存活率。抑制Jurkat T细胞中Fas介导的细胞凋亡。据报道，它也抑制肽：体外和体内的N-聚糖酶 (PNGase)。当与纯化的重组酶一起使用时，需要用酯酶进行预处理。
Biochem/physiol Actions
主靶
Fas介导的Jurkat细胞凋亡和星形孢菌素诱导的角膜上皮细胞死亡
Fas介导的Jurkat细胞凋亡和星形孢菌素诱导的角膜上皮细胞死亡
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液可在-20°C稳定6个月。
Analysis Note
TLC 单点
Other Notes
Heng, B.C., et al. 2007.Biosci.Rep.27, 257.
Martin, U., et al. 2007.Apoptosis12, 525.
Misaghi, S., et al. 2004.Chem. Biol.11, 1677.
Joo, C., et al. 1999.Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998.Mol.Cell.Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998.Science 281, 1312.
Tolomeo, M., et al. 1998.Cell Death Differ.5, 735.
An, S. and Know, K.A. 1996.FEBS Lett.386, 115.
Cain, K., et al. 1996.Biochem J.314, 27.
Mirzoeva, O.K., et al. 1996.FEBS Lett.396, 266.
Pronk, G.J., et al. 1996.Science 271, 808.
Slee, E.A., et al. 1996.Biochem.J.315, 21.
Chow, S.C., et al. 1995.FEBS Lett.364, 134.
Fearnhead, H.O., et al. 1995.FEBS Lett.375, 283.
Zhu, H., et al. 1995.FEBS Lett.374, 303.
Martin, U., et al. 2007.Apoptosis12, 525.
Misaghi, S., et al. 2004.Chem. Biol.11, 1677.
Joo, C., et al. 1999.Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998.Mol.Cell.Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998.Science 281, 1312.
Tolomeo, M., et al. 1998.Cell Death Differ.5, 735.
An, S. and Know, K.A. 1996.FEBS Lett.386, 115.
Cain, K., et al. 1996.Biochem J.314, 27.
Mirzoeva, O.K., et al. 1996.FEBS Lett.396, 266.
Pronk, G.J., et al. 1996.Science 271, 808.
Slee, E.A., et al. 1996.Biochem.J.315, 21.
Chow, S.C., et al. 1995.FEBS Lett.364, 134.
Fearnhead, H.O., et al. 1995.FEBS Lett.375, 283.
Zhu, H., et al. 1995.FEBS Lett.374, 303.
Z-Val-Ala-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 627610-1MG | 04055977262810 |
| 627610-5MG | 04055977262841 |