676492
MAZ51
≥95% (HPLC), solid, VEGFR3 kinase inhibitor, Calbiochem®
别名:
VEGFR3激酶抑制剂，MAZ51, MAZ51，3-(4-二甲氨基-萘-1-基亚甲基)-1,3-二氢-吲哚-2-酮，血管内皮生长因子受体3激酶抑制剂，VEGFR酪氨酸激酶抑制剂XVI，VEGFR3激酶抑制剂I
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关于此项目
经验公式（希尔记法）:
C21H18N2O
化学文摘社编号:
分子量:
314.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
VEGFR3激酶抑制剂，MAZ51, The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
red
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O
InChI
1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChI key
VFCXONOPGCDDBQ-UHFFFAOYSA-N
General description
一种细胞可渗透的3-取代吲哚-2-酮化合物，可作为VEGF受体酪氨酸激酶的可逆和ATP竞争性抑制剂。在低浓度（5 µM）下，据报道可在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。据报道，仅在较高浓度（50 µM）时部分阻断VEGFR-2磷酸化。这种差异抑制可能有助于控制淋巴管生成依赖性的肿瘤转移，因此对癌症治疗研究具有临床意义。
Biochem/physiol Actions
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
主靶
受体酪氨酸激酶
受体酪氨酸激酶
靶标IC50：在低浓度（≤5 µM）下，它在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。
Packaging
用惰性气体包装
Other Notes
Kirkin, V., et al. 2001.Eur. J. Biochem.268, 5530
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
Jinman Chen et al.
Nature communications, 11(1), 3159-3159 (2020-06-24)
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 676492-10MG | 04055977183689 |