681629
W-7盐酸盐
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).
别名:
W-7盐酸盐, N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
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关于此项目
经验公式（希尔记法）:
C16H21ClN2O2S · xHCl
化学文摘社编号:
分子量:
340.87 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
crystalline solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
description
RTECS - QK0786000
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
off-white
solubility
DMSO: 5 mg/mL, DMF: soluble, warm ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI key
OMMOSRLIFSCDBL-UHFFFAOYSA-N
General description
一种细胞渗透性和可逆性钙调蛋白拮抗剂，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶（C50 = 28 µM）和肌球蛋白轻链激酶（IC50 = 51 µMM）。
Biochem/physiol Actions
主靶
肌球蛋白轻链激酶
肌球蛋白轻链激酶
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：51µM，抑制肌球蛋白轻链激酶；28µM，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶
Other Notes
Caulfield, M.P., et al. 1991.Neurosci. Lett.125, 57.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Estelle R Simo-Cheyou et al.
Journal of cellular physiology, 232(12), 3496-3509 (2017-01-21)
An upregulation of Egr-1 expression has been reported in models of atherosclerosis and intimal hyperplasia and, various vasoactive peptides and growth promoting stimuli have been shown to induce the expression of Egr-1 in vascular smooth muscle cells (VSMC). Angiotensin-II (Ang-II)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 681629-10MG | 04055977260144 |