跳转至内容
Merck
CN

AB1252

抗细胞色素P450 酶CYP2E1抗体

serum, Chemicon®

别名:

cytochrome P450 2E1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
29
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助


biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CYP2E1(1571)
mouse ... Cyp2E1(13106)
rat ... Cyp2E1(25086)

General description

57kda
细胞色素P450 (CYP)是一个巨大的、多样化的血红素蛋白超家族。它可以将脂肪酸花生四烯酸(AA)代谢为血管紧张度的调节因子。
大多数CYP可以代谢多种底物,并且可以催化多种反应。这种作用导致它们在诸多内源性和外源性分子的代谢中极为重要。在肝脏中,这些底物包括药物和毒性化合物,以及代谢产物,如胆红素(血红蛋白的分解产物)。细胞色素P450 酶存在于机体的许多其它组织中,包括胃肠道的粘膜,并在激素合成和分解(包括雌激素和睾丸素合成和代谢)、胆固醇合成和维生素D代谢中起重要作用。自2007年9月以来,我们已经知道了7700多种不同的CYP序列。

Application

免疫组化:
一个先前批次被用于甲醛处理的冷冻切片。

最佳的工作稀释度必须由最终用户确定。
抗细胞色素P450 酶CYP2E1抗体是针对细胞色素P450 酶CYP2E1的抗体,可用于IH & WB。

Biochem/physiol Actions

与肝脏微粒体部分(microsomal fraction)中的人和大鼠细胞色素P450 酶CYP2E1反应。与这些物种中的其它细胞色素P450 酶没有交叉反应。

Physical form

不含防腐剂的缓冲液中的兔多克隆抗血清。

Analysis Note

对照
肝脏组织。
通过蛋白质印迹对人脑裂解物进行了评估。

蛋白质印迹分析:
该抗体的1:1000稀释液在10 μg小人脑裂解物中检测到细胞色素P450 酶CYP2E1。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany


Still not finding the right product?

试用我们的 产品选型工具 工具缩小选择范围


存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库



Conformational anti-cytochrome P4502E1 (CYP2E1) auto-antibodies contribute to necro-inflammatory injury in chronic hepatitis C.
Sutti, S, et al.
Journal of Viral Hepatitis, 17, 685-690 (2010)
Kyle J Thompson et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 52(6), 629-637 (2017-10-17)
This study sought to compare mice bred to preferentially consume high amounts of alcohol (crossed-high alcohol preferring, cHAP) to c57BL/6 (C57) mice using a chronic-binge ethanol ingestion model to induce alcoholic liver disease (ALD). Male C57 and cHAP mice were
S Vichi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 30(1 Pt A), 176-184 (2015-03-22)
Within the Predict-IV FP7 project a strategy for measurement of in vitro biokinetics was developed, requiring the characterization of the cellular model used, especially regarding biotransformation, which frequently depends on cytochrome P450 (CYP) activity. The extrahepatic in situ CYP-mediated metabolism



全球贸易项目编号

货号GTIN
AB125208436037123528