AB2237
抗PAX6抗体
from rabbit, purified by affinity chromatography
别名:
Aniridia type II protein, paired box 6, paired box gene 6, paired box gene 6 (aniridia, keratitis), paired box homeotic gene-6
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
83
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, chicken
should not react with
human
technique(s)
immunocytochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PAX6(5080)
General description
PAX6是PAX基因中研究最多的基因，在整个文献中都作为眼睛和其他感觉器官，某些神经和表皮组织以及通常源自外胚层组织的其他同源结构发育的“主控制”基因出现。这种转录因子以其在异位眼的种间诱导表达中的用途而闻名，并且具有医学重要性，因为杂合突变体会在人类中产生广泛的眼部缺陷，例如无虹膜症。该基因编码成对的盒基因6，这是果蝇基因prd的许多人类同源物之一。除了该基因家族的标志性特征，保守的配对盒结构域外，编码的蛋白，还包含同源盒结构域。已知这两个结构域都结合DNA，并且用作基因转录的调节剂。该基因在发育中的神经紧张的系统和发育中的眼睛中表达。已知该基因的突变会导致无虹膜症以及彼得斯′异常，这两种眼部疾病。
~48 kDa
Immunogen
KLH偶联，对应于C末端的PAX6
Application
免疫细胞化学：
使用1:50-1:1,000的抗Pax6工作稀释液来处理鸡脊髓中的蛋白。
使用1:50-1:1,000的抗Pax6工作稀释液来处理鸡脊髓中的蛋白。
抗PAX6抗体检测PAX6的水平 &经发布 & 经验证可用于WB & IC。
Biochem/physiol Actions
该抗体可识别PAX6的C端。
Physical form
免疫亲和纯化的兔多克隆抗体溶于含0.1M Tris-甘氨酸（pH 7.4）、150mM NaCl和0.05％ NaN3的缓冲液中。
Analysis Note
对照
小鼠和大鼠脑裂解液
小鼠和大鼠脑裂解液
通过蛋白质印迹法对大鼠和小鼠脑裂解液进行常规评估。
蛋白质印迹分析：
0.5 µg/mL的该抗体在10 µg小鼠和大鼠脑裂解液中检测到PAX6。
蛋白质印迹分析：
0.5 µg/mL的该抗体在10 µg小鼠和大鼠脑裂解液中检测到PAX6。
Other Notes
替代品：AB5409
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
实验方案
Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.
商品
Human iPSC neural differentiation media and protocols used to generate neural stem cells, neurons and glial cell types.
Jovica Ninkovic et al.
Neuron, 68(4), 682-694 (2010-11-26)
Most neurons in the adult mammalian brain survive for the entire life of an individual. However, it is not known which transcriptional pathways regulate this survival in a healthy brain. Here, we identify a pathway regulating neuronal survival in a
Keith W Vance et al.
The EMBO journal, 33(4), 296-311 (2014-02-04)
Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, we describe
Notch signaling maintains neural rosette polarity.
Main, H; Radenkovic, J; Jin, SB; Lendahl, U; Andersson, ER
Testing null
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AB2237 | 04053252513794 |