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Merck
CN

AB3500P

Anti-Anion Exchanger 1 Antibody

Chemicon®, from rabbit

别名:

AE1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
5
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

rat ... Slc4A1(24779)

Immunogen

A 20 amino acid peptide sequence near the N-terminus of rat AE1 (Kudrycki et al. 1989; Kopito et al. 1985; Raida et al. 1989; Lux et al. 1989; Tanner et al. 1988).

Application

Anti-Anion Exchanger 1 Antibody detects level of Anion Exchanger 1 & has been published & validated for use in ELISA & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western blot: 1-10 μg/mL using ECL. AE1 has a molecular weight of approximately 90-100 kDa. It aggregates easily forming dimers and multimers. It may also be proteolytically processed to smaller fragments of 60, 40 and 20 kDa.



ELISA: 1-10 μg/mL using 1 μg/mL control peptide per well.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes rat Anion Exchanger 1 (AE1). The immunogen shows no significant sequence homology with other AE or other proteins.

SPECIES REACTIVITIES: The immunogen sequence is 90% conserved in mouse, 75% in human and 70% in bovine. Reactivity with other species has not been confirmed.

Physical form

Affinity purified immunoglobulin. Liquid in Liquid in PBS with 0.1% BSA.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Nicole Gröger et al.
Human molecular genetics, 21(5), 1025-1036 (2011-11-16)
The human SLC4A5 gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status. The biochemical basis of this association is unknown particularly since no single
Nicole Gröger et al.
The Journal of biological chemistry, 285(19), 14467-14474 (2010-02-27)
Maintenance of ion concentration gradients is essential for the function of many organs, including the kidney, the cornea, and the inner ear. Ion concentrations and fluid content in the cornea are regulated by endothelial cells that separate the collagenous avascular
Sekiya Shibazaki et al.
Human molecular genetics, 17(11), 1505-1516 (2008-02-12)
Polycystic kidney disease (ADPKD) results from failure of the kidney to properly maintain three-dimensional structure after loss of either polycystin-1 or -2. Mice with kidney selective inactivation of Pkd1 during embryogenesis develop profound renal cystic disease and die from renal



全球贸易项目编号

货号GTIN
AB3500P04053252362927