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Merck
CN

AB5423

Anti-Tyrosine Hydroxylase Antibody, phosphoSer31

Chemicon®, from rabbit

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
rat
Application:
ICC, IHC, WB
Citations:
15
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biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

phosphorylation (pSer31)

Gene Information

rat ... Th(25085)

Immunogen

Epitope: phosphoSer31
Synthetic peptide from the phosphoSer31 of rat Tyrosine Hydroxylase. Available as catalog number AG398

Application

Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-Tyrosine Hydroxylase Antibody, phosphoSer31 is validated for use in IC, IH, WB for the detection of Tyrosine Hydroxylase.
Western blot: 1:1,000

Immunocytochemistry: 1:1,000

Immunohistochemistry: 1:1,000

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Tyrosine Hydroxylase, phosphoSer31. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser31 in lysates of PC-12 cells stimulated by okadaic acid.

Physical form

Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Preparation Note

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

10 - Combustible liquids

wgk

WGK 2



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M F Salvatore et al.
Journal of neurochemistry, 75(1), 225-232 (2000-06-15)
Electrical stimulation of the medial forebrain bundle increases (32)P incorporation into striatal tyrosine hydroxylase (TH) at Ser (19), Ser(31), and Ser(40). In the present studies, the effects of acute haloperidol and related drugs on sitespecific TH phosphorylation stoichiometry (PS) in
Activity-dependent phosphorylation of tyrosine hydroxylase in dopaminergic neurons of the rat retina.
Witkovsky, Paul, et al.
The Journal of Neuroscience, 24, 4242-4249 (2004)
Pilar Almela et al.
PloS one, 7(10), e47089-e47089 (2012-10-17)
Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine (DA) levels in brain regions receiving dense VTA input. Since the role of stress in drug addiction is well established



全球贸易项目编号

货号GTIN
AB542304053252287923