产品名称
抗-囊泡谷氨酸转运蛋白1抗体, serum, Chemicon®
biological source
guinea pig
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
rat ... Slc17A7(116638)
General description
62 kDa
囊泡谷氨酸转运蛋白1（VGLUT1）由定位于人类染色体19q13的基因编码。VGLUT1在大脑的神经元细胞中特异性表达。其特征在于保守的C-末端双亮氨酸样基序和C-末端远端的两个聚脯氨酸结构域，包括一个与内吞BAR（Bin/Amphiphysin/Rvs）结构域蛋白，吞蛋白结合的结构域。
Immunogen
来自大鼠VGLUT1蛋白的合成肽，与VGLUT2没有重叠。可获得的免疫原为AG208。
Application
- 已测试应用
免疫细胞化学分析：代表性批次的1：250稀释液在E18大鼠皮层细胞中检测到囊泡谷氨酸转运体1。 - 注意：实际最佳工作稀释度必须由最终用户确定，因为样本和实验条件可能会因最终用户而有所不同
Biochem/physiol Actions
识别囊泡谷氨酸转运蛋白1（VGLUT1，BNPI{脑特异性钠离子依赖性无机磷酸盐协同转运蛋白}）。已使用免疫荧光组织化学在大鼠中枢神经系统（CNS）的组织切片上测试了抗血清。抗血清主要标记神经纤维和末梢。VGLUT1是谷氨酸能神经末梢的极佳标志物。用VGLUT1抗血清获得的染色的染色模式对应于使用VGLUT1的其他抗血清描述的模式（Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002）。用免疫原肽预吸收VGLUT1抗血清可消除全部免疫染色。
Physical form
含0.1%叠氮化钠的豚鼠血清。
Other Notes
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
The regulation of corticofugal fiber targeting by retinal inputs
Grant E, et al.
Cerebral Cortex, 26(3), 1336-1348 (2016)
The expression of vesicular glutamate transporters defines two classes of excitatory synapse.
Fremeau, R T, et al.
Neuron, 31, 247-260 (2001)
N Rebola et al.
Neuroscience, 133(1), 79-83 (2005-05-17)
Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1 and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and facilitation of glutamate release have been observed, it is not clear whether both A1 and A2A receptors are located
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AB5905 | 04053252333897 |
| AG208 | 04053252282812 |