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Merck
CN

AB9983

抗酪氨酸羟化酶抗体

rabbit polyclonal

别名:

Tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase

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关于此项目

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
rat, mouse
Application:
IHC, WB
Citations:
7
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产品名称

抗酪氨酸羟化酶抗体, from rabbit

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, mouse

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Th(21823)
rat ... Th(25085)

General description

~58 kDa
酪氨酸羟化酶在肾上腺素能神经元的生理机能中起重要作用。它是从酪氨酸生物合成儿茶酚胺多巴胺和去甲肾上腺素的第一种酶和限速酶。因此,TH是一种有用的多巴胺能和去甲肾上腺素能神经元标志物。TH酶活性维持需要亚铁离子作为辅因子,且人们普遍认为其受到磷酸化作用调控。目前至少鉴定出了四种因可变剪接而产生的人TH亚型。

Immunogen

表位:C端
重组蛋白

Application

免疫组化:在大鼠和小鼠脑(石蜡包埋组织)上使用1:100工作稀释液。
抗酪氨酸羟化酶抗体可检测酪氨酸羟化酶的水平&已发表&经验证可用于IH(P)&WB。
研究子类别
神经递质& 受体
研究类别
神经科学

Biochem/physiol Actions

与其他物种的反应性尚未确定。
目录号AB9983识别酪氨酸羟化酶的C末端

Physical form

在含0.05% NaN3的0.1M Tris-甘氨酸(pH7.4)150mM NaCl中纯化
形式:纯化
抗原亲和纯化

Preparation Note

自收到之日起,在 2-8ºC 条件下可稳定保存1年

Analysis Note

对照
大鼠脑裂解物

Other Notes

浓度:请参考批次特异性浓缩物的分析证书。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



分析证书(COA)

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Michael De Santis et al.
International journal of molecular sciences, 17(11) (2016-11-24)
Prescription of antipsychotic drugs (APDs) to children has substantially increased in recent years. Whilst current investigations into potential long-term effects have uncovered some alterations to adult behaviours, further investigations into potential changes to neurotransmitter systems are required. The current study
Bo Pan et al.
PloS one, 10(7), e0132722-e0132722 (2015-07-15)
Aripiprazole is a wide-used antipsychotic drug with therapeutic effects on both positive and negative symptoms of schizophrenia, and reduced side-effects. Although aripiprazole was developed as a dopamine D2 receptor (D2R) partial agonist, all other D2R partial agonists that aimed to
Huiying Liu et al.
Journal of neurochemistry, 152(3), 397-415 (2019-08-24)
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Its pathological features are dopaminergic neuronal death in the substantia nigra (SN), and significant reduction in dopamine (DA) content in the striatum. A large number of studies



全球贸易项目编号

货号GTIN
AB998304053252409738