Anti-Periostin (Pan) Antibody

Periostin, also known as PN, or Osteoblast-specific factor 2 (OSF-2), and encoded by the gene POSTN/OSF2, is a secreted extracellular matrix protein that appears to be involved in inducing cell attachment and spreading as well as cell adhesion. In bone, Periostin enhances mineralization and assists in the incorporation of BMP1 protein into the fibronectin extracellular matrix of connective tissues. Periostin is preferentially expressed in periosteum and periodontal ligaments but can also be found expressed in developing heart and other tissues. Periostin is also over expressed in many cancers where is contributes to a growth-supportive role for such cancers and also aids in chemoresistance for cancers cells through the activation of the PI3K/Akt/surviving pathway.

~75-85 kDa observed. Uniprot describes five isoforms at 93 kDa, 90 kDa, 90 kDa, 87 Kda, and 87 kDa However, this protein has been observed between 75-85 kDa

Linear peptide from the fasciclin 1 domain of mouse periostin.

Anti-Periostin (Pan) Antibody is an antibody against Periostin (Pan) for use in western blotting & IHC.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

Western Blotting Analysis: A representative lot detected Periostin (Pan) in mouse lung extract.

Immunohistochemistry Analysis: A representative lot detected Periostin (Pan) in certain reported tissues (Kruzynska-Frejtag, A., et al. (2004). Dev Dyn. 229(4):857-868.; Butcher, J. T., et al. (2007). Dev Biol. 302(1):256-266.; Norris, R. A., et al. (2007). J Cell Biochem. 101(3):695-711.; Inai, K., et al. (2008). Dev Biol. 315(2):383-396.; Norris, R. A., et al. (2008). Dev Biol. 316(2):200-213.).

This antibody detects all splice variants of Periostin.

Affinity purified

Purified rabbit polyclonal in buffer containing PBS.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Periostin (Pan) in 10 µg of mouse lung tissue lysate.

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