biological source
human
Quality Level
assay
>97.0%
form
(Clear dry film)
manufacturer/tradename
Chemicon®
NCBI accession no.
UniProt accession no.
Gene Information
human ... APP(351)
General description
β 淀粉样蛋白 1-42是整合膜结合淀粉样前体蛋白的衍生物。它是阿尔茨海默′病肽的最重要形式。
Application
β 淀粉样蛋白 1-42, aβ, 超纯, HFIP, 重组人已用于：
- 通过膜片钳（patch-clamp）技术研究其对人星形细胞瘤细胞中线粒体BKCa（mitoBKCa）活性的影响
- 研究其对小鼠成神经细胞瘤细胞中营养不良性神经突（DN）形成蛋白的蛋白质水平变化的影响
- 诱发实验研究用大鼠模型的阿尔茨海默病
Biochem/physiol Actions
β 淀粉样蛋白1-42 导致神经毒性，并与阿尔茨海默病的发病机制有关。 β 淀粉样蛋白（βA） 可作为许多受体和其它分子的配体，参与组织和血脑屏障中的复杂运输途径（trafficking pathway）。β它和淀粉不溶素一起提高环磷酸腺苷（cAMP）和 Ca2+水平，继而激活多个信号通路介导子，如丝裂原激活蛋白激酶（MAPK）、 蛋白激酶A/B和 cFOS。它也是AD相关神经炎症的主要来源。
Preparation Note
透明干膜。以1mg/mL的浓度重悬于1% NH4OH中。溶入溶液后，超声处理30秒至1分钟。为加入您的溶液：重悬后，加入5x或10x缓冲液贮备液（PBS，TBS）和水定容至1x缓冲液。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Annika Olsson et al.
Clinical chemistry, 51(2), 336-345 (2004-11-26)
To simultaneously study several biomarkers for Alzheimer disease (AD), we used the xMAP technology to develop and evaluate a multiparametric bead-based assay for quantification of beta-amyloid((1-42)) [Abeta((1-42))], total tau (T-TAU), and hyperphosphorylated tau [P-TAU((181P))] in cerebrospinal fluid (CSF). We compared
Stephanie J Soscia et al.
PloS one, 5(3), e9505-e9505 (2010-03-09)
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AG968-1MG | 04053252513930 |