biological source
rat
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
A5, monoclonal
species reactivity
mouse, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG2aκ
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... LAMC1(3915)
General description
177kda
层粘连蛋白是细胞外基质糖蛋白的一个家族，是基底膜的主要非胶原蛋白成分。它们与多种生物学过程有关，包括细胞粘附，分化，迁移，信号传导，神经突向生长和转移。胚胎发生、器官发生、创伤后愈合和癌症中都观察到此层粘连蛋白表达变化。发现层粘连蛋白具有促进神经突再生的能力，从而激发了层粘连蛋白。层粘连蛋白由3条不同的链组成：层粘连蛋白α，β和γ（以前分别为A，B1和B2）。以前认为是β链的γ1链包含类似于β链的结构域，但是，缺少分隔结构域I和II的短α区。通过同源重组使γ1链基因的两个等位基因失活的转基因小鼠的胚胎缺乏基底膜，表明层粘连蛋白γ1链对于层粘连蛋白异源三聚体组装是必需的。
Immunogen
从小鼠EHS肿瘤制备基底膜蛋白。
Application
使用经验证可用于IH（P）的抗层粘连蛋白γ1抗体（克隆A5）检测层粘连蛋白γ1。
研究子类别
ECM蛋白
粘附（CAMs）
ECM蛋白
粘附（CAMs）
Physical form
形式：纯化
纯化的大鼠免疫球蛋白溶于含有0.1 M Tris-甘氨酸（pH7.4）150mM NaCl和0.05%NaN3的缓冲液中。
Analysis Note
对照
结肠管状癌与纤维神经瘤
结肠管状癌与纤维神经瘤
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Fenny Wiradjaja et al.
Disease models & mechanisms, 6(6), 1426-1433 (2013-09-21)
Fras1-related extracellular matrix protein 1 (FREM1) is required for epidermal adhesion during embryogenesis, and mice lacking the gene develop fetal skin blisters and a range of other developmental defects. Mutations in members of the FRAS/FREM gene family cause diseases of
Alejandro E Mayorca-Guiliani et al.
Nature protocols, 14(12), 3395-3425 (2019-11-11)
The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of limitations in ECM visualization. We recently developed an ECM-specialized method termed in situ decellularization of tissues
Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop.
Ohlund, D; Franklin, O; Lundberg, E; Lundin, C; Sund, M
BMC Cancer null
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB1914P | 04053252503191 |