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Merck
CN

MAB2000

Anti-Integrin beta 1 (CD29) Antibody

CHEMICON®, mouse monoclonal, HB1.1

别名:

CD29

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关于此项目

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
HB1.1, monoclonal
Species reactivity:
human, pig
Application:
FACS, IHC, IP, WB
Citations:
37
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产品名称

Anti-Integrin β1 Antibody, clone HB1.1, clone HB1.1, Chemicon®, from mouse

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HB1.1, monoclonal

species reactivity

human, pig

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1κ

suitability

not suitable for activity/function inhibition

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)

Application

Anti-Integrin β1 Antibody, clone HB1.1 detects level of Integrin β1 & has been published & validated for use in FC, IP, WB, IH.
Immunoprecipitation of VLA integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB2000.

Flow cytometry: 10 μg/mL

Western blot

Immunohistochemistry in frozen tissue samples: 5 μg/mL

Induction of cell aggregation: 10 μg/mL. MAB2000 is a potent stimulator of cell aggregation tested in U937, Jurkat and human peripheral blood lymphocytes.

MAB2000 does not affect VLA integrin-mediated cell adhesion to matrix proteins.

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Biochem/physiol Actions

Reacts with beta-1 subunit of VLA integrins

Physical form

Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02M PB pH 7.6, 0.25M NaCl with 0.1% sodium azide.

Preparation Note

Maintain at 2-8°C for up to 6 months after date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1109

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility.
Seales, EC; Jurado, GA; Brunson, BA; Wakefield, JK; Frost, AR; Bellis, SL
Cancer Research null
PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.
Toyoshima, F; Matsumura, S; Morimoto, H; Mitsushima, M; Nishida, E
Developmental Cell null
Pig chondrocyte xenoimplants for human chondral defect repair: an in vitro model.
Fuentes-Boquete, Isaac, et al.
Wound Repair and Regeneration, 12, 444-452 (2004)



全球贸易项目编号

货号GTIN
MAB200004053252464430