biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunocytochemistry: suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PPARA(5465)
General description
过氧化物酶体增殖物激活受体（PPAR）是核激素受体，可以被多种化合物激活，包括原纤维、噻唑烷二酮、前列腺素和脂肪酸。已经描述了三种PPAR亚型，称为PPARα、PPARβ（也称为PPARδ）和PPARγ。PPAR通过与类固醇受体的类视黄醇X受体(RXR)家族成员形成异二聚体并与称为PPAR反应元件(PPRE)的特定DNA基序结合来促进转录。PPARα在原代肝细胞中含量很高，它调节参与脂肪酸代谢的蛋白质的表达。PPARβ是分布最广泛的亚型，通常以高水平表达。PPARγ主要存在于脂肪组织中，在调节脂肪细胞分化中起关键作用。
Immunogen
来自小鼠PPARalpha氨基酸18-34的合成肽。
Application
使用经ELISA、WB、ICC验证的抗PPAR α抗体（小鼠单克隆抗体）检测PPAR alpha，也称为过氧化物酶体增殖物激活受体α。
研究子类别
转录因子
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
蛋白质印迹：1:500-1:5000
免疫细胞化学：1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
免疫细胞化学：1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
与过氧化物酶体增殖物激活受体α（PPARalpha）反应。与PPARbeta或PPARgamma无交叉反应。
Physical form
腹水液。 液体。不含防腐剂。
Preparation Note
接收后，以未稀释的等分试样在-20°C下保存长达6个月。应避免反复冻/融循环。
Analysis Note
对照
3T3全细胞裂解物
3T3全细胞裂解物
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Hao-Yu Liu et al.
Frontiers in nutrition, 8, 711398-711398 (2021-11-02)
Scope: Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian clock regulation, in association with lipid
Demin Cai et al.
Journal of cellular physiology, 236(6), 4387-4402 (2020-11-14)
Nonalcoholic-fatty-liver-disease (NAFLD) is the result of imbalances in hepatic lipid partitioning and is linked to dietary factors. We demonstrate that conjugated linoleic acid (CLA) when given to mice as a dietary supplement, induced an enlarged liver, hepatic steatosis, and increased
Yan Lu et al.
The Journal of clinical investigation, 124(8), 3501-3513 (2014-07-09)
Hepatosteatosis is characterized by an aberrant accumulation of triglycerides in the liver; however, the factors that drive obesity-induced fatty liver remain largely unknown. Here, we demonstrated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB3890 | 04053252266041 |