MAB4148
Anti-MRP2 Antibody, clone M2 I-4
culture supernatant, clone M2 I-4, Chemicon®
别名:
cMOAT
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
M2 I-4, monoclonal
Species reactivity:
human
Application:
ICC, IHC, WB
Citations:
9
biological source
mouse
Quality Level
antibody form
culture supernatant
antibody product type
primary antibodies
clone
M2 I-4, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... ABCC2(1244)
Immunogen
Fusion protein of MRP2 containing aa 215-310 of the protein.
Application
This Anti-MRP2 Antibody, clone M2 I-4 is validated for use in WB, IC, IH for the detection of MRP2.
Western blotting: 1:20 - 1:50 with anti-mouse HRP
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Päivi Myllynen et al.
Toxicology and applied pharmacology, 232(2), 210-217 (2008-08-06)
We have studied the role of ATP binding cassette (ABC) transporters in fetal exposure to carcinogens using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a known substrate for ABC transporters as a model compound. In perfusion of human term placenta, transfer of (14)C-PhIP (2 microM)
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.
Chunying Li,John D Schuetz,Anjaparavanda P Naren
Cancer letters null
C C Paulusma et al.
Science (New York, N.Y.), 271(5252), 1126-1128 (1996-02-23)
The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB4148 | 04053252615078 |