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Merck
CN

MAB4388

小鼠抗-Stella 抗体

clone 3H5.2, Chemicon®, from mouse

别名:

Anti-Anti-Pgc7, Anti-Anti-STELLA

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
3H5.2, monoclonal
Application:
ELISA, ICC
Citations:
13
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3H5.2, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, immunocytochemistry: suitable

input

sample type: human embryonic stem cell(s)
sample type induced pluripotent stem cell(s)
sample type: mouse embryonic stem cell(s)

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Dppa3(73708)

General description

Stella 是在原肠胚出现时由卵母细胞、多能细胞和原始生殖细胞特异性表达的,是小鼠胚胎裂解期的重要母体因子(Bortvin, 2004)。尽管stella在生殖细胞中特异性分化的要求仍然存有争议,但是,来自stella 缺乏小鼠的大多数胚胎无法正常发育,并很少达到囊胚期(Bortvin, 2004; Payer, 2003)。 stella 基因编码一种带有类SAP 结构域和剪接因子基序样(splicing factor motif-like)结构的蛋白,表明其在染色体组织结构和RNA 加工中的可能作用(Payer, 2003)。

Application

抗-Stella抗体可检测Stella的水平&已有相关文献发表& 经验证可用于 ELISA & IC。
研究子类别
多能&早期分化
研究类别
干细胞研究

Biochem/physiol Actions

与人和小鼠的stella 反应。

Physical form

形式:纯化
溶于含0.1%叠氮化钠的PBS中的纯化免疫球蛋白液体。

Preparation Note

以未稀释的等分形式可在2-8C冷藏保存长达12个月。

Other Notes

浓度:请参考批次特异性浓缩物的检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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相关内容

As the focus of stem cell research undergoes a transition from animal to human models, researchers are in critical need of validated products to support the isolation, maintenance, differentiation, and characterization of human stem cells. While many reagents designed for rodent systems can be applied to human stem cell studies, they are not truly optimized for robust human stem cell culture or analysis. This is why human stem cell researchers have always trusted EMD Millipore, the first provider of commercially available human embryonic stem cells and human neural stem cell lines, to accelerate their research. All of our human stem cell systems are extensively tested in defined media culture, and differentiated progeny are comprehensively characterized with highly validated antibodies and detection reagents.


Alex Bortvin et al.
BMC developmental biology, 4, 2-2 (2004-03-17)
In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in
Generation of stella-GFP transgenic mice: a novel tool to study germ cell development
Payer, Bernhard, et al
Genesis, 44, 75-83 (2006)
Bernhard Payer et al.
Current biology : CB, 13(23), 2110-2117 (2003-12-05)
stella is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos, and pluripotent cells. It encodes a protein with a SAP-like domain and a splicing factor motif-like structure, suggesting possible roles in chromosomal organization or RNA processing.



全球贸易项目编号

货号GTIN
MAB438804053252579837