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MABC282

Anti-BAG3 Antibody, clone AC-1

Name: Anti-BAG3 Antibody, clone AC-1
Brand: MM

clone AC-1, from mouse

别名:

BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

AC-1, monoclonal

Application:

IHC, IP

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AC-1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable

isotype

IgG1κ

NCBI accession no.

NP_004272

UniProt accession no.

O95817

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BAG3(9531)

说明

General description

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.

~62 kDa observed

Application

Detect BAG3 using this Anti-BAG3 Antibody, clone AC-1 validated for use in Immunoprecipitation, IHC(P).

Physical form

Format: Purified

Analysis Note

Evaluated by Immunoprecipitation in HeLa cell lysate.

Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated BAG3 from HeLa cell lysate.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival.

Alessandra Rosati et al.

The American journal of pathology, 181(5), 1524-1529 (2012-09-05)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers, being the fourth leading cause of cancer-related deaths. Long-term survival reaching 15% is achieved in less than 5% of patients who undergo surgery, and median survival is only 6

BAG3 controls angiogenesis through regulation of ERK phosphorylation.

Falco, A, et al.

Oncogene (2012)

全球贸易项目编号

货号	GTIN
MABC282	04053252823688