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MABC32

抗-p62（死骨片-1）抗体，克隆11C9.2

clone 11C9.2, from mouse

别名:

sequestosome 1, EBI3-associated protein of 60 kDa, Paget disease of bone 3, phosphotyrosine independent ligand for the Lck SH2 domain p62, oxidative stress induced like, EBI3-associated protein p60, Phosphotyrosine-independent ligand for the Lck SH2 doma

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
11C9.2, monoclonal
Application:
FACS, ICC, WB
Citations:
18
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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

11C9.2, monoclonal

species reactivity

mouse, rat, human

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_001135770

UniProt accession no.

Q13501

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SQSTM1(8878)

General description

p62也称为sequestosome-1，是62 kDa ras-GAP相关蛋白。p62被认为与Src家族酪氨酸激酶结合，并且还可以为活化的Src家族激酶及其下游效应子提供接头作用。p62具有RNA结合区，可能具有RNA结合能力。p62与转录因子NF-κB的激活有关，参与细胞分化、免疫反应和钾通道调节。p62最近与外在细胞凋亡有关，可能是肿瘤发生的关键因素。
观测分子量约47-60 kDa。
该蛋白的计算分子量为47 kDa，在38 kDa处也具有亚型。由于修饰，在某些裂解物中可观察到高达〜60 kDa的该蛋白。

Immunogen

GST标记的重组蛋白，对应于人p62（Sequestosome-1）。

Application

使用经验证可用于WB、FC&IC的抗p62（Sequestosome-1）抗体（克隆11C9.2）检测p62（Sequestosome-1）。
研究子类别
凋亡 - 附加
研究类别
细胞凋亡 & 癌症
蛋白质印迹分析：0.001 µg/mL的先前批次在10 µg PC12细胞裂解物中检测到p62（Sequestosome-1）。

流式细胞术分析：1.0 µg的先前批次在固定和透性化HeLa细胞染色中检测到p62（Sequestosome-1）。

免疫细胞化学分析：一个先前批次以1:500稀释度在NIH/3T3、A431和HeLa细胞中检测到p62（Sequestosome-1）。

Physical form

形式：纯化
纯化的小鼠单克隆IgMκ，溶于含0.05%叠氮化钠的PBS的缓冲液中。

Preparation Note

自接收之日起，在2-8°C下可稳定保存1年。

Analysis Note

对照
A431细胞裂解物
通过蛋白质印迹法在A431细胞裂解物中进行评估。

蛋白质印迹分析：0.001 µg/mL该抗体在10 µg A431细胞裂解物中检测到p62（Sequestosome-1）。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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货号GTIN
MABC3204053252681813