MILLIPLEX^® Multi-Species TGFß Panel

The transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 3 analytes in multi-species serum, plasma, and cell culture supernatants.

Analytes included: TGF-β1, TGF-β2, TGF-β3
Note: This assay requires a sample acidification treatment using the provided reagents and protocol.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Triple Isoform Detection: Simultaneously quantifies TGFβ1, TGFβ2, and TGFβ3, providing a complete profile of TGFβ signaling.

Wide Species Reactivity: Verified for human, mouse, rat, pig, hamster, guinea pigs, and non-human primates.

Includes Sample Acidification Protocol: To measure active TGFβ, samples must undergo acid treatment. This step is critical for converting latent TGFβ into its active form, ensuring accurate quantification.

Wide Dynamic Range: Standard curve spans 9.8–10,000 pg/mL.

Versatile Applications: Ideal for basic research, translational studies, and therapeutic development.

Luminex is a registered trademark of Luminex Corporation

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.