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Merck
CN

07386

辅酶 Q10

analytical standard

别名:

Q-10, 辅酶Q10, 辅酶Q50

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关于此项目

经验公式(希尔记法):
C59H90O4
化学文摘社编号:
分子量:
863.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-147-9
Beilstein/REAXYS Number:
1900141
MDL number:
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grade

analytical standard

Quality Level

assay

≥97.5% (HPLC)

form

powder

shelf life

limited shelf life, expiry date on the label

impurities

≤1.0% water

color

faint yellow to dark orange

mp

49 °C

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

General description

辅酶Q10是线粒体呼吸链中的中心电子载体,来源于食物摄入以及内源合成。它通常以还原形式起作用,可防止生物膜和血清低密度脂蛋白(LDL)中的脂质过氧化。它往往可以保护线粒体膜蛋白和DNA免受脂质过氧化引起的氧化损伤。

Application


  • Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice:研究表明辅酶Q10可通过抗氧化机制和炎症调节有效减轻心脏损伤,提供人体治疗参考(Antar et al., 2024)。

  • Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10:研究辅酶Q10及牛磺酸如何缓解氯丙嗪所致血液不良反应,体现它对付精神治疗副反应的作用(Obukohwo et al., 2024)。

  • Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms:讨论辅酶Q10在肌肉健康中的作用,尤其它可通过线粒体支持防止肌肉萎缩并增强细胞能量代谢,与运动医学和衰老研究紧密相关(Shen et al., 2024)。

  • Identification of a family of species-selective complex I inhibitors as potential anthelmintics:本文与辅酶Q10间接相关,研究重点涉及的线粒体功能,与辅酶Q10在同类通路上的作用有关。代表在寄生虫学和传染病领域的新应用意义(Davie et al., 2024)。

Other Notes

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析(使用数字化外标)。可查看该物质的NMR谱图,只需点击几次鼠标,就能进行在线样品比对。欢迎点击了解更多,开启免费试用之旅。

Disclaimer

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
Gerwyn Morris et al.
Molecular neurobiology, 48(3), 883-903 (2013-06-14)
Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and
Meghan J Ho et al.
The Cochrane database of systematic reviews, (4)(4), CD007435-CD007435 (2009-10-13)
Studies have shown that coenzyme Q10 deficiency is associated with cardiovascular disease. Hypertension is a commonly measured surrogate marker for non-fatal and fatal cardiovascular endpoints such as heart attacks and strokes. Clinical trials have suggested that coenzyme Q10 supplementation can



全球贸易项目编号

货号GTIN
115053-1G04061821000002
115053-25G04061832104928
115053-5G04061838703057
07386-10MG04061835560073