32097
依托考昔
VETRANAL®, analytical standard
别名:
5-氯-3-[4-(甲磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶, 5-氯-6′-甲基-3-[4-(甲磺酰基)苯基]]-2,3′-联吡啶
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关于此项目
经验公式（希尔记法）:
C18H15ClN2O2S
化学文摘社编号:
分子量:
358.84
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8073797
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
SMILES string
CC1=NC=C(C2=C(C3=CC=C(S(C)(=O)=O)C=C3)C=C(Cl)C=N2)C=C1
InChI
1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
InChI key
MNJVRJDLRVPLFE-UHFFFAOYSA-N
Gene Information
human ... PTGS2(5743)
General description
依托考昔是一种非甾体类环加氧酶-2（COX-2）选择性抗炎药，主要用于骨关节炎和类风湿性关节炎患者的治疗。
Application
依托考昔已被用作参考标准品，用于通过液相色谱-串联质谱-常压化学电离分析法（LC-APCI/MS/MS）检测人血浆中的依托考昔。
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 4 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
Shruti Setia et al.
Molecular and cellular biochemistry, 366(1-2), 89-99 (2012-03-14)
Roles of cyclooxygenase (COX) enzyme and intrinsic pathway of apoptosis have been explored for the chemopreventive effects of non-steroidal anti-inflammatory drugs (NSAIDs) on 9,10-dimethyl benz(a)anthracene (DMBA)-induced lung cancer in rat model. 16 weeks after the administration of DMBA, morphological analysis
V Dahl et al.
Acta anaesthesiologica Scandinavica, 56(1), 95-101 (2011-11-23)
Many studies have demonstrated that either COX-2 antagonists or glucocorticoids are efficient analgesics after orthopaedic surgery. We wanted to evaluate if the combination of these two drugs was better than one drug alone when added to paracetamol, local anaesthesia, and
I L Meek et al.
European journal of clinical pharmacology, 69(3), 365-371 (2012-08-15)
Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) are often prescribed concurrently in patients with nociceptive pain and cardiovascular comorbidity. NSAIDs and ASA inhibit the same COX-enzymes, and thus may interact. ASA's cardioprotective antiplatelet effect is entirely COX-1 dependent. NSAIDs
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 32097-25MG | 04061826702130 |