32473
甲氧氯普胺
VETRANAL®, analytical standard
别名:
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
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关于此项目
经验公式（希尔记法）:
C14H22ClN3O2
化学文摘社编号:
分子量:
299.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-662-9
Beilstein/REAXYS Number:
1884366
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI
1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI key
TTWJBBZEZQICBI-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), HTR3A(3359), HTR4(3360)
General description
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
Application
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
G S De Oliveira et al.
British journal of anaesthesia, 109(5), 688-697 (2012-09-28)
Previous evidence suggested that 10 mg systemic metoclopramide is not effective to prevent postoperative nausea and/or vomiting (PONV) in patients receiving general anaesthesia. However, the evidence included data with questioned validity by the author Yoshitaka Fujii. The objective of the
Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Vlase L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(3), 652-657 (2007)
Metoclopramide: pharmacology and clinical application.
Albibi R and McCALLUM RW
Annals of Internal Medicine, 98(1), 86-95 (1983)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 32473-100MG | 04061826711712 |