33899
诺氟沙星
VETRANAL®, analytical standard
别名:
1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸, 1-乙基-6-氟-1,4-二氢-4-氧代-7-哌嗪-3-喹啉羧酸
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关于此项目
经验公式（希尔记法）:
C16H18FN3O3
化学文摘社编号:
分子量:
319.33
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
274-614-4
MDL number:
grade
analytical standard
Quality Level
agency
EPA 1694
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3
InChI
1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChI key
OGJPXUAPXNRGGI-UHFFFAOYSA-N
General description
诺氟沙星是一种抗菌药物，属于氟喹诺酮类（FQ），对多种革兰氏阴性和革兰氏阳性菌具有广谱抗菌活性。
Application
诺氟沙星可作为分析参考标准品，通过各种色谱技术对药物制剂、生物体液和污水中的分析物进行测定。
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。
Biochem/physiol Actions
诺氟沙星通过干扰 ATP 诱导转换 DNA 与 DNA 旋转酶（拓扑异构酶）复合物的结构转换而阻断 DNA 复制。
操作方式：抑制细菌 DNA 复制
抗菌谱：革兰氏阴性菌； 对革兰氏阳性菌效果较差
操作方式：抑制细菌 DNA 复制
抗菌谱：革兰氏阴性菌； 对革兰氏阳性菌效果较差
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Determination of ofloxacin, norfloxacin, and ciprofloxacin in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry.
Lee B-H, et al.
Journal of Chromatography A, 1139(1), 45-52 (2007)
Deepika Sharma et al.
European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
Lauren Becnel Boyd et al.
Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)
Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 638293-5G | 04061831822182 |
| 638293-1G | 04061825586908 |
| 33899-100MG-R | 04061826745670 |