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45674

红霉素

Name: 红霉素
Brand: SIAL

tested according to Ph. Eur.

别名:

红霉素

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关于此项目

经验公式（希尔记法）:

C₃₇H₆₇NO₁₃

化学文摘社编号:

114-07-8

分子量:

733.93

UNSPSC Code:

51282304

NACRES:

NA.76

PubChem Substance ID:

329756889

EC Number:

204-040-1

Beilstein/REAXYS Number:

75279

MDL number:

MFCD00084654

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属性

Quality Level

200

agency

tested according to Ph. Eur.

form

solid

color

white to faint yellow

solubility

H₂O: soluble 2 mg/mL, acetone: freely soluble, acetonitrile: freely soluble, alcohol: soluble, amyl acetate: moderately soluble, chloroform: soluble, diethyl ether: soluble, ethyl acetate: freely soluble

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

application(s)

environmental

mode of action

protein synthesis | interferes

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)

说明

General description

Chemical structure: macrolide

Application

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Biochem/physiol Actions

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

Packaging

25g

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Disclaimer

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

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商品

抗生素对蛋白质合成的抑制作用

蛋白质合成是一个复杂、多步骤过程，涉及到很多酶以及构象排列。但是，阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

Erythromycin is a motilin receptor agonist.

T Peeters et al.

The American journal of physiology, 257(3 Pt 1), G470-G474 (1989-09-01)

Erythromycin A (EMA) is a potent stimulator of gastrointestinal motor activity. In vitro studies suggest that it mimics motilin, a peptide that stimulates motor activity in human and in rabbit via smooth muscle receptors. We have compared the in vitro

Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.

Anna C Shore et al.

Antimicrobial agents and chemotherapy, 54(12), 4978-4984 (2010-10-06)

The staphylococcal cfr gene mediates resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A, a phenotype that has been termed PhLOPS(A). The cfr gene has mainly been associated with coagulase-negative staphylococcal isolates from animals, and only a few cfr-positive methicillin-resistant

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments.

Elisabet I Nielsen et al.

Antimicrobial agents and chemotherapy, 51(1), 128-136 (2006-10-25)

Dosing of antibacterial agents is generally based on point estimates of the effect, even though bacteria exposed to antibiotics show complex kinetic behaviors. The use of the whole time course of the observed effects would be more advantageous. The aim

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全球贸易项目编号

货号	GTIN
1086939025	04061841163886
1086931000	04061841163862
1086932500	04061841163879
40166-1G	04061826269923
45674-25G-F	04061832341644

主要文件

红霉素

tested according to Ph. Eur.

选择尺寸

关于此项目

Quality Level

agency

form

color

solubility

antibiotic activity spectrum

application(s)

mode of action

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Packaging

Preparation Note

Other Notes

Disclaimer

Still not finding the right product?

安全信息

存储类别

flash_point_f

flash_point_c

ppe

法规信息

文件

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