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61739

N-月桂酰肌氨酸

Name: <I>N</I>-月桂酰肌氨酸
Brand: SIAL

≥98.0% (GC), suitable for protein quantification, purum p.a.

别名:

N-十二烷酰基-N-甲基甘氨酸, 肌氨酰 L

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关于此项目

线性分子式:

CH₃(CH₂)₁₀CON(CH₃)CH₂COOH

化学文摘社编号:

97-78-9

分子量:

271.40

NACRES:

NA.21

PubChem Substance ID:

57651861

UNSPSC Code:

12352100

EC Number:

202-608-3

MDL number:

MFCD00021749

Beilstein/REAXYS Number:

1792084

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属性

产品名称

N-月桂酰肌氨酸, purum p.a., ≥98.0% (GC)

description

anionic

Quality Level

200

grade

purum p.a.

assay

≥98.0% (GC)

mol wt

271.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.2% water

ign. residue

≤0.1%

mp

45-50 °C

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤100 mg/kg

cation traces

Ca: ≤20 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤10 mg/kg, K: ≤70 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤200 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤20 mg/kg

functional group

amide, carboxylic acid

SMILES string

CCCCCCCCCCCC(=O)N(C)CC(O)=O

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

InChI key

BACYUWVYYTXETD-UHFFFAOYSA-N

说明

General description

N-月桂酰肌氨酸（N-十二烷酰基-N-甲基甘氨酸，Sarkosyl L，LS）是一种阴离子表面活性剂。已经研究了其在小鼠模型中对单纯疱疹病毒2型（HSV-2）阴道内感染的杀伤作用。

Application

N-月桂酰肌氨酸可用作透皮制剂中的透皮增强剂，因为它能够增强皮肤角质层脂质结构的流动性†

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H315,H318,H330

pcodes

P260 - P264 - P280 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yoshiaki Furukawa et al.

The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)

The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here

Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol.

Yeu-Chun Kim et al.

International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)

To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery

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货号	GTIN
61739-25G	04061835555338
61739-5G	04061832700618