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关于此项目
经验公式(希尔记法):
C6H6N6O2
化学文摘社编号:
分子量:
194.15
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
assay
≥99.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
ign. residue
≤0.2%
loss
≤0.5% loss on drying
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
SMILES string
CN1N=Nc2c(ncn2C1=O)C(N)=O
InChI
1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key
BPEGJWRSRHCHSN-UHFFFAOYSA-N
General description
替莫唑胺(TMZ)是一种咪唑并四嗪衍生物的烷化剂,显示出针对鼠肿瘤的广谱抗肿瘤活性。
Application
TMZ可作为一种参考标准品通过胶束电动毛细管色谱(MEKC)对血清和脑肿瘤、液相色谱-电喷雾-串联质谱(LC-ESI-MS/MS)对水相溶液、带有MS/MS的高效液相色谱(HPLC)对活性药物成分(API)以及配备有光电二极管阵列(PDA)检测器的HPLC对药物剂型中的替莫唑胺进行分析。
有关合适仪器技术的更多信息,请参考产品′s分析证书。如需进一步支持,请联系技术服务。
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography-electrospray-tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution.
Negreira N, et al.
Talanta, 116(23), 290-299 (2013)
Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Andrasi M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879(23), 2229-2233 (2011)
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma.
Kim H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 421693-1G | 04061837394393 |
| 76899-10MG | 04061832924830 |

