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Merck
CN

76899

替莫唑胺

VETRANAL®, analytical standard

别名:

3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺, 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺, 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺, 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, NSC 362856

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关于此项目

经验公式(希尔记法):
C6H6N6O2
化学文摘社编号:
分子量:
194.15
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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grade

analytical standard

Quality Level

product line

VETRANAL®

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

ign. residue

≤0.2%

loss

≤0.5% loss on drying

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CN1N=Nc2c(ncn2C1=O)C(N)=O

InChI

1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChI key

BPEGJWRSRHCHSN-UHFFFAOYSA-N

General description

替莫唑胺(TMZ)是一种咪唑并四嗪衍生物的烷化剂,显示出针对鼠肿瘤的广谱抗肿瘤活性。

Application

TMZ可作为一种参考标准品通过胶束电动毛细管色谱(MEKC)对血清和脑肿瘤、液相色谱-电喷雾-串联质谱(LC-ESI-MS/MS)对水相溶液、带有MS/MS的高效液相色谱(HPLC)对活性药物成分(API)以及配备有光电二极管阵列(PDA)检测器的HPLC对药物剂型中的替莫唑胺进行分析。
有关合适仪器技术的更多信息,请参考产品′s分析证书。如需进一步支持,请联系技术服务。

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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分析证书(COA)

Lot/Batch Number

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Negreira N, et al.
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Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Andrasi M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879(23), 2229-2233 (2011)
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma.
Kim H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001)



全球贸易项目编号

货号GTIN
421693-1G04061837394393
76899-10MG04061832924830