80822
(S)-Naproxen methyl ester
pharmaceutical impurity standard
别名:
Naproxen Impurity E (PhEur), (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester, Methyl (αS)-6-methoxy-α-methyl-2-naphthaleneacetate, Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
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关于此项目
经验公式（希尔记法）:
C15H16O3
化学文摘社编号:
分子量:
244.29
UNSPSC Code:
12352108
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4352971
Quality Level
API family
naproxen
assay
≥98.0% (HPLC)
optical activity
[α]/D 72.0 to 84.0°, c = 0.1 in chloroform
shelf life
limited shelf life, expiry date on the label
impurities
≤0.5% water
mp
87 °C
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
C[C@H](C(OC)=O)C1=CC2=CC=C(OC)C=C2C=C1
InChI
1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1
InChI key
ZFYFBPCRUQZGJE-JTQLQIEISA-N
General description
(S)-Naproxen methyl ester is an ester of the non-steroidal, anti-inflammatory drug, (S)-naproxen
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bulletin of the Chemical Society of Japan, 77(1-4) (2004)
Enantioselective hydrolysis of racemic naproxen methyl ester by two-step acetone-treated Candida rugosa lipase.
Lee GE, et al.
Process Biochemistry (Oxford, United Kingdom), 37(3), 293-298 (2001)
Sammy Ferri-Borgogno et al.
Cancers, 12(9) (2020-09-25)
Background & Aims: ARID1A is postulated to be a tumor suppressor gene owing to loss-of-function mutations in human pancreatic ductal adenocarcinomas (PDAC). However, its role in pancreatic pathogenesis is not clear despite recent studies using genetically engineered mouse (GEM) models.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 80822-50MG | 04061832992129 |