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E1700000

雌素酮

Name: 雌素酮
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

3-羟基雌甾-1,3,5(10)-三烯-17-酮, 雌(三烯酚)酮, 雌酮

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₂O₂

化学文摘社编号:

53-16-7

分子量:

270.37

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329799017

MDL number:

MFCD00003620

Beilstein/REAXYS Number:

1915077

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属性

grade

pharmaceutical primary standard

agency

EP Reference Standard

API family

estrone

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

258-260 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

Gene Information

human ... ESR1(2099)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Estrone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P270 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects.

Shanshan Zhao et al.

Breast cancer research : BCR, 16(2), R30-R30 (2014-03-29)

Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women's Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex

Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells.

Yoko Urata et al.

The Journal of clinical endocrinology and metabolism, 98(4), 1583-1590 (2013-03-02)

Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) expression in endometrioma stromal cells (ESCs) and increases the

Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction.

Sheikh O Jobe et al.

Hypertension (Dallas, Tex. : 1979), 61(2), 480-487 (2013-01-16)

Estrogens and estrogen metabolites have important functions in cardiovascular and other physiology, yet the patterns of estrogen synthesis, metabolism, and the individual plasma profile of estrogens and estrogen metabolites during human pregnancy as well as in preeclampsia remain undetermined. We

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全球贸易项目编号

货号	GTIN
E1700000	04061833793312