biological source
synthetic (organic)
agency
USP/NF, meets USP testing specifications
assay
98.0-101.5% dry basis
form
solid
shelf life
limited shelf life,expiry date on the label
mp
194-196 °C
solubility
water: soluble 50 g/L
application(s)
pharmaceutical (small molecule)
storage temp.
room temp
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChI key
FBSMERQALIEGJT-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)
Application
在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
Biochem/physiol Actions
吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。
氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Rafaa Zeineddine et al.
Molecular neurodegeneration, 10, 57-57 (2015-11-02)
Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission of infectious prions. Cell-to-cell transmission of SOD1 protein aggregates is dependent on fluid-phase endocytosis pathways, although
Jessica M D'Amico et al.
Journal of neurophysiology, 109(6), 1473-1484 (2012-12-12)
In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents
Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.
Rosanne Varkevisser et al.
Pflugers Archiv : European journal of physiology, 465(2), 247-259 (2012-11-30)
Drug-induced ion channel trafficking disturbance can cause cardiac arrhythmias. We showed that the antiprotozoic pentamidine decreased K(IR)2.x carried I(K1) current and that inhibiting protein degradation in the lysosome increased intracellular K(IR)2.1 levels. In this study, we aim to identify and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C0982-5G | 04061834401919 |
| C0982-25G | 04061833453032 |