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C8856

卡托普利

Name: 卡托普利
Brand: SIAL

meets USP testing specifications

别名:

N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸

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关于此项目

经验公式（希尔记法）:

C₉H₁₅NO₃S

化学文摘社编号:

62571-86-2

分子量:

217.29

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24893111

EC Number:

263-607-1

Beilstein/REAXYS Number:

477887

MDL number:

MFCD00168073

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属性

biological source

synthetic (organic)

Quality Level

200

agency

USP/NF, meets USP testing specifications

assay

97.5-102.0% dry basis

form

crystalline

mp

104-108 °C (lit.)

storage temp.

room temp

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Gene Information

human ... ACE(1636), ECE1(1889)
rat ... Ace(24310)

说明

Biochem/physiol Actions

血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成，血管紧张素 II 是生物活性多肽，可促进血管生成并增加微血管密度。

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pictograms

GHS08

signalword

Danger

hcodes

H341,H360F

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Blockade of the renin-angiotensin system improves the early stages of liver regeneration and liver function.

Shir Lin Koh et al.

The Journal of surgical research, 179(1), 66-71 (2012-11-01)

Partial hepatectomy is the preferred option for selected patients with colorectal cancer liver metastases (CRCLM). Sufficient liver regeneration (LR) is essential for a successful outcome in these patients. The blockade of the renin-angiotensin system (RAS) reduces the growth of several

A novel splice-site mutation in angiotensin I-converting enzyme (ACE) gene, c.3691+1G>A (IVS25+1G>A), causes a dramatic increase in circulating ACE through deletion of the transmembrane anchor.

Alexandre Persu et al.

PloS one, 8(4), e59537-e59537 (2013-04-06)

Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active peptides and plays a key role in blood pressure regulation and vascular remodeling. Elevated ACE levels are associated with different cardiovascular and respiratory diseases. Two Belgian families with a 8-16-fold increase

Antihypertensive effects of extract from Picrasma quassiodes (D. Don) Benn. in spontaneously hypertensive rats.

Wenna Zhao et al.

Journal of ethnopharmacology, 145(1), 187-192 (2012-11-13)

ETHNOPHARMACOLOGICA RELEVANCE: Picrasma quassiodes (D. Don) Benn. (PQB) is a widely used herbal medicine used for gastroenteritis, snakebite, infection and hypertension in China. The aim of the study was to investigate the possible antihypertensive mechanisms on spontaneously hypertensive rats (SHR)

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全球贸易项目编号

货号	GTIN
C8856-5G	04061833522912
C8856-1G	04061833522905
C8856-25G	04061834402213