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C8981

卡马西平

meets USP testing specifications

别名:

5H-二苯并[b,f]氮杂-5-甲酰胺

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关于此项目

经验公式（希尔记法）:
C15H12N2O
化学文摘社编号:
298-46-4
分子量:
236.27
NACRES:
NA.21
PubChem Substance ID:
24893120
UNSPSC Code:
41116107
EC Number:
206-062-7
MDL number:
MFCD00005073
Form:
solid
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agency

USP/NF, meets USP testing specifications

form

solid

mp

191-192 °C (lit.)

storage temp.

2-8°C

SMILES string

NC(=O)N1c2ccccc2C=Cc3ccccc13

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

InChI key

FFGPTBGBLSHEPO-UHFFFAOYSA-N

Gene Information

human ... PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Biochem/physiol Actions

抗惊厥药；GABAA受体苯二氮卓调节位点的配体。钠离子通道抑制剂。

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

target_organs

Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCD8191
MKCK0972
MKBZ7693V
MKBX8835V
SLBH2762V

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The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for alpha2beta3gamma2 and alpha3beta3gamma2 GABA(A)-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of
Ursula Amstutz et al.
Epilepsia, 55(4), 496-506 (2014-03-07)
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Janneke Jentink et al.
BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
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全球贸易项目编号

货号GTIN
C8981-25G04061833523070
C8981-5G04061833523087