grade
pharmaceutical primary standard
API family
deferoxamine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
General description
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。 如需进一步信息和支持，请访问现行药典网站。
Application
甲磺酸去铁胺EP参考标准品的预期用途是欧洲药典规定的实验室测试。
Biochem/physiol Actions
一种铁螯合剂，常用于研究细胞增殖和凋亡。 体外 和 体内 实验均显示其对血管平滑肌细胞具有抗增殖作用，并抑制G1期细胞的增殖。 据报道，它也诱导p53。 通过螯合铁诱导HL-60细胞凋亡。 经过1μM去铁胺处理48小时后，DNA明显断裂。 细胞经0.1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。 一些研究表明，它具有抗氧化性能，并保护细胞免受H2O2诱导的损伤。
一种铁螯合剂，常用于研究细胞增殖和凋亡。据报道，它也诱导p53。
Packaging
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
Other Notes
可能适用相应的销售限制。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Xueping Guo et al.
PloS one, 9(4), e94156-e94156 (2014-04-17)
Hyaluronidases are a family of enzymes that degrade hyaluronic acid (hyaluronan, HA) and widely used in many fields. A hyaluronidase producing bacteria strain was screened from the air. 16S ribosomal DNA (16S rDNA) analysis indicated that the strain belonged to
Joao Fonseca et al.
Oncology letters, 17(1), 697-705 (2019-01-19)
Resveratrol (RES) is a polyphenol produced by certain plant species that has been well studied due to its ability to slow the growth of cancer cells. In numerous cell types and tissues, RES has been demonstrated to promote mitochondrial biogenesis
Jingyin Yue et al.
Genes & development, 34(9-10), 637-649 (2020-04-04)
The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest commonly referred to as
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D0160000 | 04061833557532 |