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关于此项目
经验公式（希尔记法）:
C29H32O13
化学文摘社编号:
分子量:
588.56
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
pharmaceutical primary standard
API family
etoposide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
InChI
1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key
VJJPUSNTGOMMGY-MRVIYFEKSA-N
Gene Information
human ... TOP2A(7153), TOP2B(7155)
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Etoposide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
依托泊甙是一种抗肿瘤试剂，和拓扑异构酶II和DNA结合，增强DNA双链和单链剪切和可逆抑制解除。 在S期和G2期阻止细胞周期；诱导正常和肿瘤细胞系凋亡；抑制癌蛋白Mdm2的合成，引起Mdm2过量表达的肿瘤系细胞凋亡。
抗肿瘤试剂，和拓扑异构酶II和DNA结合，增强DNA双链和单链剪切和可逆抑制解除。
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Sachiko Ezoe
International journal of environmental research and public health, 9(7), 2444-2453 (2012-08-02)
Etoposide is an anticancer agent, which is successfully and extensively used in treatments for various types of cancers in children and adults. However, due to the increases in survival and overall cure rate of cancer patients, interest has arisen on
Y-L Kwong et al.
Leukemia, 28(4), 865-870 (2013-07-12)
Circulating Epstein-Barr virus (EBV) DNA is a biomarker of EBV-associated malignancies. Its significance in natural killer/T-cell lymphoma treated with the novel regimen SMILE was investigated. EBV DNA was quantified with a World Health Organization EBV standard in 910 plasma samples
Abukar Ali et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 107-116 (2014-10-11)
Permanent reduction in joint function is a severe postinfectious complication in patients with Staphylococcus aureus septic arthritis. We undertook this study to determine whether this reduction in joint function might be caused by persistent joint inflammation after the adequate eradication
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E2600000 | 04061833602751 |