E4378
乙二醇-双（2-氨基乙醚）-N,N,N′,N′-四乙酸
≥97.0%
别名:
Chel™-DE, EGTA, 乙二醇醚二胺四乙酸, 乙烯-双（氧乙烯硝基）四乙酸, 依他酸
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关于此项目
线性分子式:
[-CH2OCH2CH2N(CH2CO2H)2]2
化学文摘社编号:
分子量:
380.35
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-651-2
Beilstein/REAXYS Number:
1717370
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥97.0%
form
powder
reaction suitability
reagent type: chelator
loss
≤1.0% loss on drying
mp
241 °C (dec.) (lit.)
solubility
1 M NaOH: 1.1 g/10 mL, clear, colorless
storage temp.
room temp
SMILES string
OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
InChI key
DEFVIWRASFVYLL-UHFFFAOYSA-N
General description
在水中的溶解性随 pH 值增加而增加
Application
一种螯合剂，可在镁存在的情况下对钙进行测定。
乙二醇双(2-氨基乙醚)四乙酸(EGTA)可用于：
- 作为大鼠主动脉弓缩窄术(TAC)用低温心脏停跳液的组分
- 作为冰冷裂解缓冲液组分，用于蛋白提取和全细胞提取
- 作为HEK293F细胞线粒体提取用缓冲液A、B和C的组分
Biochem/physiol Actions
乙二醇双(2-氨基乙醚)四乙酸(EGTA)A是一种螯合剂，可在镁存在的情况下对钙进行测定。
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存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
Walter Marcotti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5505-5514 (2014-04-18)
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) channels and mediate the electrical responses of sensory hair cells. We found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to
Anita C Bellail et al.
Nature communications, 5, 4234-4234 (2014-06-24)
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6
David R Whitfield et al.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 23(2), 141-148 (2014-06-24)
Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E4378-250G | 04061833603697 |
| E4378-100G | 04061833603673 |
| E4378-10G | 04061835544462 |
| E4378-1KG | 04061833603680 |
| E4378-25G | 04061833603703 |
| E4378-500G | 04061835544479 |