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I7905

布洛芬

Name: 布洛芬
Brand: SIAL

meets USP testing specifications

别名:

α-甲基-4-(异丁基)苯乙酸, (±)-2-(4-异丁基苯基)丙酸

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₈O₂

化学文摘社编号:

15687-27-1

分子量:

206.28

NACRES:

NA.21

PubChem Substance ID:

24896130

UNSPSC Code:

12352106

EC Number:

239-784-6

MDL number:

MFCD00010393

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属性

Quality Level

200

agency

USP/NF, meets USP testing specifications

form

solid

application(s)

pharmaceutical (small molecule)

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

Gene Information

human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290), Ptgs1(24693)

说明

Application

A Case of Erythema Nodosum in a 20-Year-Old Female During the Postpartum Period.：详细报道1例布洛芬参与治疗结节性红斑的临床病例。说明本品的治疗应用及相关风险(Nguyen M et al., 2024)。

Coracoclavicular Joint Arthrosis - An Uncommon Cause of Shoulder Pain.：研究用布洛芬治疗罕见关节病相关的疼痛。加深了解骨科疾病中的疼痛管理(Graça NNJ et al., 2024)。

Biochem/physiol Actions

环加氧酶 (COX) 抑制剂，对 COX-1 的抑制活性大于对 COX-2 的抑制活性。

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pictograms

GHS07

signalword

Warning

hcodes

H302,H319,H335

pcodes

P261 - P264 - P271 - P280 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Stereoselective disposition of ibuprofen enantiomers in synovial fluid.

R O Day et al.

Clinical pharmacology and therapeutics, 43(5), 480-487 (1988-05-01)

The simultaneous disposition of the enantiomers of ibuprofen in synovial fluid and plasma was studied in eight patients with arthritis. Concentrations of the active S-enantiomer in synovial fluid exceeded those of the R-enantiomer at all times in all patients with

Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial.

Bart Van Overmeire et al.

Lancet (London, England), 364(9449), 1945-1949 (2004-11-30)

Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed

Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.

Zhangjian Huang et al.

Journal of medicinal chemistry, 54(5), 1356-1364 (2011-02-02)

The carboxylic acid group of the anti-inflammatory (AI) drugs indo-methacin, (S)-naproxen and ibuprofen was covalently linked via a two-carbon ethyl spacer to a sulfohydroxamic acid moiety (CH(2)CH(2)SO(2)NHOH) to furnish a group of hybrid ester prodrugs that release nitric oxide (NO)

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全球贸易项目编号

货号	GTIN
I7905-10G	04061833858400
I7905-1G	04061833858417
I7905-5G	04061833858424