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N5410

烟酸

Name: 烟酸
Brand: SIAL

meets USP testing specifications

别名:

3-吡啶甲酸, 吡啶-3-羧酸, 尼亚生, 抗糙皮病因子, 维生素 B₃

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关于此项目

经验公式（希尔记法）:

C₆H₅NO₂

化学文摘社编号:

59-67-6

分子量:

123.11

UNSPSC Code:

12352106

NACRES:

NA.21

PubChem Substance ID:

24897734

EC Number:

200-441-0

Beilstein/REAXYS Number:

109591

MDL number:

MFCD00006391

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属性

biological source

synthetic (organic)

Quality Level

200

agency

USP/NF, meets USP testing specifications

assay

99.0-101.0% dry basis

form

powder

color

white

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

说明

General description

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

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pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Pellagra: a non-eradicated old disease

Savvidou S

Clinics and practice, 4(1) (2014)

Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line

Lelong-Rebel I, et al.

Anticancer Research, 28(1A), 55-68 (2008)

Niacin and oxidative stress: a mini-review

Ilkhani F, et al.

Journal of Nutritional Medicine and Diet Care, 2(1), 2-14 (2008)

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全球贸易项目编号

货号	GTIN
N5410-100G	04061835547050