biological source
synthetic (organic)
Quality Level
grade
reagent grade
form
powder
mp
100-104 °C (lit.)
solubility
methanol: 200 mM (Stock solution is stable for months at –20° C.)
SMILES string
O.c1cnc2c(c1)ccc3cccnc23
InChI
1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
InChI key
PPQJCISYYXZCAE-UHFFFAOYSA-N
Gene Information
human ... FNTA(2339)
General description
菲咯啉是一种杂环有机化合物,可与金属离子形成络合物。这些络合物在生物化学、催化和分析化学领域应用广泛。与铁络合,可作为氧化还原指示剂。
Application
1,10-菲咯啉一水合物用于:
- 用作MDA-MB-231乳腺癌细胞金属蛋白酶(MMP)的抑制剂
- 用作小鼠心脏样本原位酶谱分析的阴性对照品
- 体外白藜芦醇螯合以及螯合铁的还原活性测定
当与铜络合时,具有核酸酶活性,用于研究 DNA-蛋白质相互作用。
Biochem/physiol Actions
金属蛋白酶抑制剂;可与铁、锌和其他二价金属形成螯合物。有效浓度 1-10mM。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans
Soares MV, et al.
Free Radical Research, 52(9), 939-951 (2018)
Katy Satué et al.
Acta veterinaria Hungarica, 68(1), 79-84 (2020-05-10)
In women and females of different species of laboratory animals, oestrogens stimulate the renin-angiotensin-aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Progesterone and cortisol compete with aldosterone for mineralocorticoid receptors, which
Central Role of Phenanthroline Mono-N-oxide in the Decomposition Reactions of Tris (1, 10-phenanthroline) iron (II) and-iron (III) Complexes
Beller G, et al.
Inorganic Chemistry, 49(9), 3968-3970 (2010)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P9375-1G | 04061834402886 |
| P9375-100G | 04061835548064 |
| P9375-25G | 04061834402916 |
| P9375-5G | 04061834504887 |

