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PHR1383

腺嘌呤

Name: 腺嘌呤
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

腺嘌呤, 6-氨基嘌呤, 维生素 B₄

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关于此项目

经验公式（希尔记法）:

C₅H₅N₅

化学文摘社编号:

73-24-5

分子量:

135.13

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823360

EC Number:

200-796-1

Beilstein/REAXYS Number:

5777

MDL number:

MFCD00041790

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0230000, traceable to USP 1012101

API family

adenine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

>360 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

InChI key

GFFGJBXGBJISGV-UHFFFAOYSA-N

说明

General description

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

腺嘌呤是一种嘌呤核碱基，在体内和体外具有广泛的化学和生化作用。它是一种调控分子，是DNA、RNA、辅因子（NAD、FAD）和信号分子（cAMP）的组成部分。

Application

腺嘌呤可用作药物标准品，用于通过高效液相色谱技术和毛细管电泳对输液溶液中的分析物进行定量。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

Analysis Note

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

Other Notes

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

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Development and validation of a high-performance liquid chromatography assay and a capillary electrophoresis assay for the analysis of adenosine and the degradation product adenine in infusions

Keibling P, et al.

Journal of Pharmaceutical and Biomedical Analysis, 36(3), 535-539 (2004)

Rilpivirine versus efavirenz with emtricitabine/tenofovir disoproxil fumarate in treatment-naïve HIV-1-infected patients with HIV-1 RNA ≤100,000 copies/mL: week 96 pooled ECHO/THRIVE subanalysis.

Georg Behrens et al.

AIDS patient care and STDs, 28(4), 168-175 (2014-03-26)

The once daily, single-tablet regimen (STR) combining rilpivirine (RPV), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) provides a simplified treatment option for antiretroviral therapy (ART)-naïve patients with baseline HIV-1 RNA (BLVL) of ≤100,000 copies/mL. The aim of this analysis is

Identification of small molecules that support human leukemia stem cell activity ex vivo.

Caroline Pabst et al.

Nature methods, 11(4), 436-442 (2014-02-25)

Leukemic stem cells (LSCs) are considered a major cause of relapse in acute myeloid leukemia (AML). Defining pathways that control LSC self-renewal is crucial for a better understanding of underlying mechanisms and for the development of targeted therapies. However, currently

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全球贸易项目编号

货号	GTIN
PHR1383-1G	04061834416210