PHR1424
氨苄西林 钠盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
氨苄青霉素 钠盐
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关于此项目
经验公式（希尔记法）:
C16H18N3NaO4S
化学文摘社编号:
分子量:
371.39
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-708-1
Beilstein/REAXYS Number:
4119211
MDL number:
Quality Level
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. A1000000, traceable to USP 1033203
API family
ampicillin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
215 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
InChI
1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
InChI key
KLOHDWPABZXLGI-YWUHCJSESA-M
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Ampicillin Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography with ultra violet detection and second-derivative spectrophotometry, respectively.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
作用方式：该β-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。
耐药性机制：β-内酰胺酶切开氨苄青霉素的β-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
耐药性机制：β-内酰胺酶切开氨苄青霉素的β-内酰胺环,使其失去活性。
抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA2732 in the slot below. This is an example certificate only and may not be the lot that you receive.
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signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Determination of mixtures of ampicillin and cloxacillin in pharmaceuticals by second-derivative spectrophotometry
Morelli B
Analytica Chimica Acta, 209, 175-184 (1988)
Mohamed F Mohamed et al.
PloS one, 9(12), e116259-e116259 (2015-01-01)
Staphylococcus pseudintermedius is a major cause of skin and soft tissue infections in companion animals and has zoonotic potential. Additionally, methicillin-resistant S. pseudintermedius (MRSP) has emerged with resistance to virtually all classes of antimicrobials. Thus, novel treatment options with new
Yuraporn Sahasakul et al.
The British journal of nutrition, 112(3), 408-415 (2014-06-17)
Lactobacilli are indigenous microbes of the stomach of rodents, with much lower numbers being present in mice fed a purified diet than in those fed a non-purified diet. We postulated that gastric emptying (GE) is responsible for the different colonisation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PHR1424-1G | 04061834416388 |