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PHR1442

氟尼辛葡甲胺

Name: 氟尼辛葡甲胺
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氟尼辛葡甲胺, 2-[[2-甲基-3-（三氟甲基）苯基]氨基] -3-吡啶羧酸葡甲胺盐, 氟尼辛甲葡胺

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₁F₃N₂O₂·C₇H₁₇NO₅

化学文摘社编号:

42461-84-7

分子量:

491.46

NACRES:

NA.24

PubChem Substance ID:

329822603

UNSPSC Code:

41116107

EC Number:

255-836-0

MDL number:

MFCD01725419

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000443, traceable to USP 1274607

API family

flunixin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F

InChI

1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChI key

MGCCHNLNRBULBU-WZTVWXICSA-N

说明

General description

Flunixin meglumine is a nonsteroidal anti-inflammatory drug and a potent cyclo-oxygenase (COX) inhibitor. It is commonly used as an analgesic and antipyretic in animals.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Flunixin meglumine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.

氟尼辛葡甲胺（IC₅₀ = 1 nM）可用作动物药物，用于治疗马的肠缺血、绞痛和内毒素血症。

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

COX1、COX2 和 PLA2 抑制剂非麻醉性镇痛、解热、抗炎。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA2750 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Chapter 3.6.3 Flunixin

Textbook of Rabbit Medicine, 137-177 (2014)

Spectrophotometric Methods for Simultaneous Determination of Oxytetracycline HCl and Flunixin Meglumine in Their Veterinary Pharmaceutical Formulation

Merey HA, et al.

Journal of Analytical Methods in Chemistry, 2017 (2017)

Micellar high performance liquid chromatographic determination of flunixin meglumine in bulk, pharmaceutical dosage forms, bovine liver and kidney

Belal FF, et al.

Analytical Chemistry Research, 3, 63-69 (2015)

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全球贸易项目编号

货号	GTIN
PHR1442-1G	04061834416609