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PHR1517

硫酸二氢链霉素

Name: 硫酸二氢链霉素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

双氢链霉素倍半硫酸酯

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关于此项目

线性分子式:

C₂₁H₄₁N₇O₁₂ · 3/2H₂SO₄

化学文摘社编号:

5490-27-7

分子量:

730.71

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823433

EC Number:

226-823-7

Beilstein/REAXYS Number:

3894221

MDL number:

MFCD00070252

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. D1954000, traceable to USP 1203008

API family

dihydrostreptomycin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)CO)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)CO)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H41N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChI key

CZWJCQXZZJHHRH-YZTFXSNBSA-N

说明

General description

Dihydrostreptomycin sulfate is a semi-synthetic broad-spectrum aminoglycoside antibiotic produced commonly by the reduction of streptomycin. It is used primarily in the treatment of tuberculosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Dihydrostreptomycin sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB9924 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361fd

pcodes

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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商品

Determination of Eight Aminoglycosides in Pork Meat

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery^® DSC-18 SPE and Ascentis^® Express C18 UHPLC, per Chinese standards.

Use of experimental design to optimize a triple-potential waveform to develop a method for the determination of streptomycin and dihydrostreptomycin in pharmaceutical veterinary dosage forms by HPLC-PAD

Martinez MM, et al.

Journal of Pharmaceutical and Biomedical Analysis, 104(5), 81-89 (2015)

A synthesis of dihydrostreptomycin

Yamasaki T, et al.

The Journal of Antibiotics, 31(12), 1233-1237 (1978)

Veterinary use and antibiotic resistance

Teuber M

Current Opinion in Microbiology, 4(5), 493-499 (2001)

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全球贸易项目编号

货号	GTIN
PHR1517-500MG	04061834418337