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Merck
CN

PHR1594

盐酸美他环素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

美他环素 盐酸盐, 盐酸甲烯土霉素

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关于此项目

经验公式(希尔记法):
C22H22N2O8 · HCl
化学文摘社编号:
分子量:
478.88
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
223-568-3
Beilstein/REAXYS Number:
5470951
MDL number:
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Quality Level

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1397006

API family

methacycline

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Cl[H].[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H22N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31);1H/t10-,14-,15+,17+,22+;/m1./s1

InChI key

VZQARNDJLLWXGL-CCHMMTNSSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methacycline hydrochloride is one of the tetracycline antibiotics effective against a broad-spectrum of Gram-positive and Gram-negative bacteria. It is formed as an intermediate during the preparation of oxytetracycline. Its antibacterial activity is higher than that of tetracycline and oxytetracycline. It finds applications in human and veterinary medications as well as feed additives.

Application

Methacycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2077 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.


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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Methacycline hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary (2013)
Ion selective PVC membrane electrode for the determination of methacycline hydrochloride in pharmaceutical formulation
Aboul-Enein H, et al.
Sensors, 2(10), 424-431 (2002)
Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column
Monser L and Darghouth F
Journal of Pharmaceutical and Biomedical Analysis, 23(2-3), 353-362 (2000)



全球贸易项目编号

货号GTIN
PHR1594-1G04061834431589