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PHR1764

秋水仙素

Name: 秋水仙素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

秋水仙碱, (S)-N-(5,6,7,9-四氢-1,2,3,10-四甲氧基-9-氧苯并[a]庚搭烯-7-基）乙酰胺

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₅NO₆

化学文摘社编号:

64-86-8

分子量:

399.44

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823598

EC Number:

200-598-5

Beilstein/REAXYS Number:

2228813

MDL number:

MFCD00078484

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2580000, traceable to USP 1146006

API family

colchicine, thiocolchicoside

CofA

current certificate can be downloaded

packaging

pkg of 400 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

150-160 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Gene Information

human ... TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H340

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Colchicine intoxication: clinical pharmacology, risk factors, features, and management.

Putterman C, et al.

Seminars in Arthritis and Rheumatism, 21(3), 143-155 (1991)

Rapid and sensitive liquid chromatography?tandem mass spectrometry method for the quantitation of colchicine in human plasma

Jiang Y. et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 850(1-2), 564-568 (2007)

Colchicine

Wyatt D K, et al.

Anal. Profiles Drug Subst., 10, 139-182 (1981)

全球贸易项目编号

货号	GTIN
PHR1764-400MG	04061835080014