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S0930000

丙戊酸钠

Name: 丙戊酸钠
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

丙戊酸钠盐, 2-丙基戊酸, 2-丙戊酸钠, 丙戊酸钠

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关于此项目

经验公式（希尔记法）:

C₈H₁₅NaO₂

化学文摘社编号:

1069-66-5

分子量:

166.19

NACRES:

NA.24

PubChem Substance ID:

329824186

UNSPSC Code:

41116107

MDL number:

MFCD00078604

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属性

grade

pharmaceutical primary standard

API family

sodium valproate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].CCCC(CCC)C([O-])=O

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

Gene Information

human ... ALDH5A1(7915)

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。

Application

丙戊酸钠EP 参考标准品设计用于欧洲药典规定的实验室测试。

Biochem/physiol Actions

抗惊厥剂，也有作为双相情感障碍情绪稳定剂的功效。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

Other Notes

可能适用相应的销售限制。

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361d

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway.

Pengfei Shi et al.

BMC cancer, 14, 370-370 (2014-06-03)

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of the natural killer group 2D (NKG2D) ligands on tumor cells; however, the mechanisms vary in different tumor types, and the effect

D-Cycloserine ameliorates social alterations that result from prenatal exposure to valproic acid.

Kristen A Wellmann et al.

Brain research bulletin, 108, 1-9 (2014-08-19)

Prenatal exposure to valproic acid (VPA) alters rodent social interactions in a dose-dependent way: exposure to a high dose of VPA (>500 mg/kg) mid-gestation decreases social interactions whereas a moderate dose of VPA (350 mg/kg) increases peer-directed social behavior. The

Increased sociability and gene expression of oxytocin and its receptor in the brains of rats affected prenatally by valproic acid.

Peter Štefánik et al.

Pharmacology, biochemistry, and behavior, 131, 42-50 (2015-02-11)

Autism is a neurodevelopmental disorder characterised by the disruption of social interactions. Autistic animal models play a crucial role in neurophysiologic research on this disorder. One of these models is based on rats that have been prenatally treated with valproic

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全球贸易项目编号

货号	GTIN
S0930000	04061836831004