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S6501

链霉素硫酸盐

Name: 链霉素 硫酸盐
Brand: SIAL

powder

别名:

2-[(1S,2R,3R,4S,5R,6R)-5-(diaminomethylideneamino)-2-[(2R,3S,4S,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyl-oxolan-2-yl]oxy-3,4,6-trihydroxy-cyclohexyl]guanidine

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线性分子式:

C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄

化学文摘社编号:

3810-74-0

分子量:

728.69

UNSPSC Code:

51281675

NACRES:

NA.76

PubChem Substance ID:

24899705

EC Number:

223-286-0

Beilstein/REAXYS Number:

3894995

MDL number:

MFCD00037023

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属性

biological source

Streptomyces griseus

Quality Level

200

form

powder

potency

≥720 I.U. per mg

mol wt

calculated mol wt 1457.38

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

说明

General description

(C₂₁H₃₉N₇O₁₂)₂ ⋅3H₂O₄S

化学结构：氨基糖苷类

Application

链霉素可用于研究链霉素抗性的机制，并常与青霉素以及其他药物一起用于抑制细胞培养应用中的细菌污染。推荐以25-50μg/mL用于分子生物学应用，100 mg/L用于细胞培养应用以及50 mg/L用于胚胎培养。

Biochem/physiol Actions

作用机制：链霉素可通过与30S核糖体亚基的S12蛋白结合而抑制原核生物蛋白的合成，从而阻止了从模拟复合物向链延长核糖体的转变。这会导致编码错误或抑制启动。

耐药性机制：rpsL这种S12核糖体蛋白基因中的突变可阻止链霉素与核糖体结合。一种氨基糖苷磷酸转移酶也可使链霉素失活。

抗菌谱：链霉素能够对抗革兰氏阴性和革兰氏阳性菌。

Preparation Note

储备液应用无菌水直接在小瓶中进行制备，浓度在20-25 mg/mL之间。

Other Notes

保存于密闭容器内，置于干燥通风处。置于干燥处保存。

Disclaimer

溶液可以在2-8°C下储存最长一个月，或在-20°C下储存更长时间。储备液可在37°C稳定三天。

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361fd

pcodes

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品

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抗生素对蛋白质合成的抑制作用

蛋白质合成是一个复杂、多步骤过程，涉及到很多酶以及构象排列。但是，阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

European species of Hypocrea Part I. The green-spored species.

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Studies in mycology, 63, 1-91 (2009-10-15)

At present 75 species of Hypocrea have been identified in temperate Europe. Nineteen green-spored species and their Trichoderma asexual states are here described in detail. Extensive searches for Hypocrea teleomorphs in 14 European countries, with emphasis on Central Europe, yielded

Impedimetric cell-based biosensor for real-time monitoring of cytopathic effects induced by dengue viruses.

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Biosensors & bioelectronics, 70, 74-80 (2015-03-22)

We describe an impedimetric cell-based biosensor constructed from poly-l-lysine (PLL)-modified screen-printed carbon electrode for real-time monitoring of dengue virus (DENV) infection of surface-immobilized baby hamster kidney (BHK-21) fibroblast cells. Cytopathic effects (CPE) induced by DENV-2 New Guinea C strain (including

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全球贸易项目编号

货号	GTIN
S6501-1KG	04061835549627
S6501-50G	04061835549641
S6501-100G	04061835549610
S6501-10KG	04061833352076
S6501-25G	04061835549634
S6501-5G	04061835516810

主要文件

链霉素 硫酸盐

powder

选择尺寸

关于此项目

biological source

Quality Level

form

potency

mol wt

storage condition

color

antibiotic activity spectrum

mode of action

storage temp.

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

Preparation Note

Other Notes

Disclaimer

Still not finding the right product?

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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全球贸易项目编号

链霉素硫酸盐