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S9251

对氨基苯磺酰胺

≥98%

别名:

对氨基苯磺酰胺

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关于此项目

线性分子式:
H2NC6H4SO2NH2
化学文摘社编号:
63-74-1
分子量:
172.20
NACRES:
NA.76
PubChem Substance ID:
24899829
eCl@ss:
39093202
UNSPSC Code:
51283932
EC Number:
200-563-4
MDL number:
MFCD00007939
Beilstein/REAXYS Number:
511852
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Quality Level

200

assay

≥98%

form

powder or crystals

color

white to off-white

mp

164-166 °C (lit.)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

Nc1ccc(cc1)S(N)(=O)=O

InChI

1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

InChI key

FDDDEECHVMSUSB-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)
mouse ... Car13(71934), Car5a(12352)

General description

化学结构：磺胺

Biochem/physiol Actions

磺胺类抗生素通过抑制酶二氢蝶酸合成酶能够阻止二氢叶酸合成。
作用模型：一种二氢蝶酸合成酶竞争性抑制剂阻止二氢叶酸合成。
抗微生物谱：革兰氏阳性，革兰氏阴性，衣原体病
抗性模型：二氢蝶酸合成酶取代或二氢叶酸合成取代途径。

Other Notes

保持容器密闭，置于干燥通风处。

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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCC4508
SLCB7799
SLCB1821
SLBX8231
SLBW9311

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I Meneau et al.
Antimicrobial agents and chemotherapy, 48(7), 2610-2616 (2004-06-25)
Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of
Edward E Knaus et al.
Bioorganic & medicinal chemistry letters, 21(19), 5892-5896 (2011-08-20)
A series of compounds incorporating regioisomeric phenylethynylbenzenesulfonamide moieties has been investigated for the inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, IX and XII. Inhibition between the low nanomolar to the milliomolar range has been
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 20(7), 2178-2182 (2010-03-10)
A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified characterized kinetically and for inhibition with a series of water soluble glycosylated sulfanilamides. bsCA 1 has appreciable activity as catalyst for the
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全球贸易项目编号

货号GTIN
S9251-500G04061835549900
S9251-100G04061835549894