biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
tretinoin
form
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
mp
180-181 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
General description
本品根据现行药典要求提供和指定。所有为支持本产品而提供的信息，包括SDS和任何产品信息小册子，均根据现行药典制定和发布。更多信息和支持请访问药典颁发机构网站。
维甲酸是一种用于治疗各种皮肤病的药物，如光损伤皮肤、痤疮等。它用作抗衰老产品，也用作白血病的口服药物。
维甲酸是一种用于治疗各种皮肤病的药物，如光损伤皮肤、痤疮等。它用作抗衰老产品，也用作白血病的口服药物。
Application
本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。
Biochem/physiol Actions
全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。
Packaging
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
Other Notes
可能适用相应的销售限制。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Tretinoin: The Active Retinoid Medication Used for Treatment of Acne Fast and Effectively (2019)
Bogdan Jakiela et al.
American journal of respiratory cell and molecular biology, 51(2), 229-241 (2014-03-05)
Human rhinoviruses (RVs) are a major cause of exacerbations in asthma and other chronic airway diseases. A characteristic feature of asthmatic epithelium is goblet cell metaplasia and mucus hypersecretion. Bronchial epithelium is also an important source of lipid mediators, including
A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
Tashtoush BM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3) (2007)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T1850000 | 04061837338281 |