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Y0000588

文拉法辛

Name: 文拉法辛
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

文拉法辛盐酸盐, (+/-)-1-[2-(二甲基氨基)-1-(4-甲氧基苯基)乙基]环己醇盐酸盐, 盐酸文拉法辛

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₇NO₂ · HCl

化学文摘社编号:

99300-78-4

分子量:

313.86

NACRES:

NA.24

PubChem Substance ID:

329831037

UNSPSC Code:

41116107

MDL number:

MFCD03658865

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属性

grade

pharmaceutical primary standard

API family

venlafaxine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2

InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

InChI key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Venlafaxine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

文拉法辛是一种 5-羟色胺-去甲肾上腺素再摄取抑制剂，其 Ki 值分别为 82 和 2480 nM。它是一种普通的抗抑郁药。

文拉法辛是抗抑郁药。文拉法辛在人中的抗抑郁作用机制与其在中枢神经系统中神经递质活性的增强有关。文拉法辛是神经元 5-羟色胺和去甲肾上腺素再摄取的有效抑制剂，是多巴胺再摄取的弱抑制剂。在体外，文拉法辛对毒蕈碱、组胺能或 α-1 肾上腺素能受体无明显活性。文拉法辛不具有 MAO 抑制剂活性。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Hazard Classifications

Aquatic Chronic 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The spectrum of acute heart failure after venlafaxine overdose.

M Batista et al.

Clinical toxicology (Philadelphia, Pa.), 51(2), 92-95 (2013-01-11)

Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicity following large overdose. The purpose of this short case series is to present different patterns of venlafaxine-related cardiotoxicity and to discuss the potential mechanisms. Between January 2010 and

The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database.

R L Rudolph et al.

Journal of clinical psychopharmacology, 16(3 Suppl 2), 54S-59S (1996-06-01)

The tolerability and safety of venlafaxine hydrochloride, a new serotonin and norepinephrine reuptake inhibitor, are reviewed in this article. The data presented here are based on a pool of 3,082 patients who were treated with this agent during clinical trials.

Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.

Aaron S Heller et al.

The American journal of psychiatry, 170(2), 197-206 (2012-12-12)

OBJECTIVE Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain

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货号	GTIN
Y0000588	04061833795842