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关于此项目
经验公式（希尔记法）:
C17H14F3N3O2S
化学文摘社编号:
分子量:
381.37
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
pharmaceutical primary standard
API family
celecoxib
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
Cc1ccc(cc1)-c2cc(nn2-c3ccc(cc3)S(N)(=O)=O)C(F)(F)F
InChI
1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
InChI key
RZEKVGVHFLEQIL-UHFFFAOYSA-N
Gene Information
human ... PTGS2(5743)
General description
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。
Application
塞来昔布EP参考标准品的预期用途是欧洲药典规定的实验室测试。
Biochem/physiol Actions
塞来昔布是一种非甾体类抗炎药 (NSAID) 和环氧化酶-2 (COX-2) 选择性抑制剂。
塞来昔布是一种非甾体类抗炎药 (NSAID) 和环氧化酶-2 (COX-2) 选择性抑制剂。塞来昔布对 COX-2 的选择性至少是 COX-1 的 10-20 倍。
Packaging
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
Other Notes
可能适用相应的销售限制。
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signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 1 - Repr. 1B - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Paul L McCormack
Drugs, 71(18), 2457-2489 (2011-12-07)
Celecoxib (Celebrex®) was the first cyclo-oxygenase (COX)-2 selective inhibitor (coxib) to be introduced into clinical practice. Coxibs were developed to provide anti-inflammatory/analgesic activity similar to that of nonselective NSAIDs, but without their upper gastrointestinal (GI) toxicity, which is thought to
Sheena Derry et al.
The Cochrane database of systematic reviews, 10(10), CD004233-CD004233 (2013-10-24)
This is an update of a review first published in The Cochrane Library in Issue 4, 2008, and updated in Issue 3, 2012. Celecoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor usually prescribed for the relief of chronic pain in osteoarthritis
Marta Garcia et al.
BJU international, 113(5b), E164-E177 (2013-10-17)
To assess whether celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor with anti-cancer properties, has an inhibitory effect on tumour establishment and progression of prostate cancer (PCa) bone metastases. PC-3 stable luciferase-expressing cells were injected into male nude mice by intracardiac (i.c.)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| Y0001445 | 04061837584572 |